Searchable abstracts of presentations at key conferences in obesity
Obesity Abstracts (2019) 1 P38 | DOI: 10.1530/obabs.01.P38

UKCO2019 Poster Presentations (1) (64 abstracts)

Quantification of true inter-individual variability in exercise-induced changes in body weight and composition and markers of appetite in individuals with overweight and obesity

Kristine Beaulieu 1 , Mark Hopkins 1 , Catherine Gibbons 1 , Phillipa Caudwell 2 , John Blundell 1 & Graham Finlayson 1

1University of Leeds, Leeds, UK; 2Novo Nordisk A/S, Bagsvaerd, Denmark.

Background: There is increasing evidence that exercise training may facilitate weight management via improvements in appetite control. However, the meaningfulness of inter-individual variability in exercise-induced changes has recently been challenged.

Methods: This study examined the individual variability in body weight and composition, and markers of appetite in response to a supervised 12-week exercise intervention (2500 kcal/week) in inactive individuals with overweight and obesity (n=46, 30 females/16 males; BMI=30.6±3.8 kg/m2; age=43.2±7.5 years) compared to non-exercising controls (n=15; 9 females/6 males; BMI=31.4±3.7 kg/m2; age=41.4±10.7 years). Body weight and composition, hunger, daily food intake, food reward and eating behaviour traits were assessed at baseline and post-intervention. SD of the true individual response to the intervention (SDIR) was calculated for each outcome. The mean body weight change and the individual response variability (2xSDIR) was interpreted against a minimum clinically important difference of 2.5 kg. For other outcomes, the magnitude of SDIR (standardized effect size; ES) was interpreted.

Results: The intervention produced a body weight loss of 1.8±2.9 kg in Exercisers (P<0.001), compared to a gain of 1.3±1.6 kg in Controls (P=0.06). The mean group difference (Exercise-Controls) in body weight was −3.1 kg (95%CI=−4.3 to −1.9 kg), with an SDIR of 2.4 kg (95%CI=1.4 to 3.1 kg), a clinically meaningful small-to-moderate effect (ES=0.17, 95%CI=0.10 to 0.22). In the Exercisers, there was also true exercise-induced individual variability in body fat percentage (ES=0.22, 95%CI=0.06 to 0.30), fat mass (ES=0.21, 95%CI=−0.07 to 0.31), restraint (ES=0.74, 95%CI=0.45 to 0.95), susceptibility to hunger (ES=0.46, 95%CI=−0.17 to 0.68) and binge eating (ES=0.47, 95%CI=0.23 to 0.63). For fasting and daily hunger ratings, food intake, food reward and disinhibition, both groups had a high degree of variability relative to the SDIR, which suggests individual variability independent of the exercise intervention. Outcomes need to be interpreted with caution as sample size was small and uncertainty high.

Conclusions: These data suggest existence of true inter-individual variability in exercise-induced weight loss and some markers of appetite that was small to large in magnitude.

Keywords: Exercise, inter-individual variability, weight loss, body composition, appetite

Disclosures: None.

Volume 1

UK Congress on Obesity 2019

Leeds, United Kingdom
12 Sep 2019 - 13 Sep 2019

Association for the Study of Obesity 

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