Searchable abstracts of presentations at key conferences in obesity
Obesity Abstracts (2019) 1 P60 | DOI: 10.1530/obabs.01.P60

UKCO2019 Poster Presentations (1) (64 abstracts)

Early pregnancy maternal adiposity measures and adverse pregnancy outcomes: A systematic review

Nicola Heslehurst 1 , Louise Hayes 1 , Vikki Smith 2 , Adefisayo Odeniyi 1 , Angela Flynn 3 , Lem Ngongalah 1 , Alexandre Simon 4 , Lisa Crowe 1 , Fiona Beyer 1 , Becky Skidmore 4 & Laura Gaudet 4

1Newcastle University, Newcastle upon Tyne, UK; 2Northumbria University, Newcastle upon Tyne, UK; 3Kings College London, London, UK; 4The Ottawa Hospital, Ottawa, Ontario, Canada.

Background: Observational studies demonstrate significant associations between pre-pregnancy obesity (defined as BMI≥30 kg/m2) and adverse pregnancy outcomes (e.g. gestational diabetes mellitus [GDM]). Although BMI is a good indicator of population health, there is strong evidence in non-pregnant populations that it is a poor indicator of individual risk compared with alternative (e.g. waist circumference). There is a lack of comprehensive evidence on alternative measures to BMI in pregnancy. This systematic review aimed to identify associations between alternative measures of adiposity to BMI and pregnancy outcomes.

Methods: Ten electronic databases were searched in January 2019, supplemented by citation and reference list searches and contacting authors. Observational studies were included if they reported early pregnancy (<20 weeks) adiposity measures and any pregnancy outcomes. Studies were excluded if they were restricted to specific populations (e.g. women with PCOS), or were focussed on low adiposity/undernutrition. Screening, data extraction and quality assessments were carried out in duplicate. Assessment of suitability for pooling studies for meta-analyses is ongoing.

Results: Searches identified 78 studies that met the inclusion criteria (n=84,962 women). Studies were published between 1995 and 2019, and quality was rated as high (n=44) and medium (n=34). Studies were from Asia (n=25), North America (n=21), Europe (n=19), South/Central America (n=5), Australia (n=4), Africa (n=3) and multi-continent (n=1). Studies predominantly reported early pregnancy waist circumference. Additional adiposity measures reported were: circumferences (arm, thigh, calf, neck, wrist); ratios (waist:hip, waist:height, neck:thigh); skinfolds (tricep, bicep, supra-iliac, subscapular, abdominal); ultrasound (subcutaneous, visceral fat); and bio-impedence (fat/fat free/lean mass). The pregnancy outcome data predominantly related to GDM. Additional outcomes reported include birth weight/fetal growth, pre/post-term birth, pre-eclampsia, caesarean, perinatal death, neonatal ICU admission, and other maternal and perinatal conditions (e.g. anaemia, jaundice). Associations between BMI and pregnancy outcomes were reported by 47 studies which will enable a comparison to be carried out between the use of BMI and alternative measures in early pregnancy.

Conclusions: Synthesis is ongoing. The potential benefits of identifying accurate adiposity risk prediction measures include the development of more targeted and cost effective intervention for those women with increased risk.

Volume 1

UK Congress on Obesity 2019

Leeds, United Kingdom
12 Sep 2019 - 13 Sep 2019

Association for the Study of Obesity 

Browse other volumes

Article tools

My recent searches

No recent searches.