Obesity Abstracts

Background: Obesity has largely been associated with type 2 diabetes, while people with type 1 diabetes (T1DM) are usually lean at diagnosis. Given the growing prevalence of obesity in the general population, people with T1DM are at increased risk of weight gain, insulin resistance and developing ‘double diabetes (DD)’. People with DD are at increased risk of micro/macrovascular complications and mortality. In this study we aimed to examine the prevalence and impact ...

SGLT2 inhibitors (SGLT2Is) are increasingly prescribed for patients with Type 2 Diabetes (T2D) as they are associated with cardiovascular benefit and weight loss with low risk of hypoglycaemia. However, in the last few years, euglycemic ketoacidosis has emerged as a recognized complication of treatment with SGLT2I. The challenge lies in delayed recognition and treatment as it can be easily overlooked due to the conspicuous absence of marked hyperglycaemia. Ketoacidosis can als...

Bariatric surgery has increasingly been associated with complications including hyperinsulinaemic hypoglycaemia associated primarily with early and late dumping syndrome, with a suggested prevalence of 0.36% (1). The symptoms can be extremely problematic with late dumping often presenting several years after surgery (1). Here we summarise the management in two such patients. Case 1: A 44 year old lady with a history of successful Roux-en-Y gastric bypass surgery (6 years prior...

Aims: Liraglutide 3 mg once daily is an approved, prescription injectable Glucagon Like Peptide-1 receptor agonist that, when used with a low-calorie diet and increased physical activity, can reduce excess weight in patients with obesity. MiRNAs are small non-coding single stranded RNAs that regulate gene expression post-transcriptionally by inhibiting their mRNA target translation into proteins. MiRNAs can be secreted in the blood stream and affect the molecular pathways of d...