Obesity Abstracts

With the global increase in obesity and diabetes, the use of weight negative therapy, such as the glucagon-like peptide -1 receptor agonists (GLP-1 RA) are increasing. The most common side effects with the GLP-1RA are gastrointestinal symptoms, mainly nausea. Other common adverse effects include headache, injection site reactions, and are usually minor and do not result in cessation of therapy. GLP-1RA are also associated with slowed gastric emptying, by virtue of their mode o...

Introduction: It is known that bariatric operations cause nutritional deficiencies especially calcium and vitamin D. Reported hypocalcemia after bariatric surgery ranges from 1% after Roux-en-Y gastric bypass (RYGB) to 25% after bilio-pancreatic diversion-duodenal switch. This is mainly the result of bypassing the preferential sites for calcium and vitamin D absorption. Apart from the bariatric operations, hypocalcemia commonly...

Background: Not all obese individuals exhibit abnormal cardiometabolic parameters. These are termed as being metabolically healthy obese (MHO). Conversely some normal weight individuals exhibit adverse cardiometabolic parameters and are described as being metabolically unhealthy normal weight (MUHNW). Visceral adiposity is known to be strongly associated with cardiometabolic risk than subcutaneous adiposity. Furthermore, there are gender differences in distribution of fat and ...

Background: Several studies have investigated the association between vitamin D receptor (VDR) variants and the risk of cardiometabolic complications. The pleiotropic action of VDR in extra-skeletal tissues gives physiologic plausibility to the associations between VDR variants and metabolic health, particularly in obese individuals. Whilst multiple conflicting findings have been reported, clinical data has shown that despite an increase in physical activity and nurturing heal...

Background: Resting energy expenditure (REE) and diet induced thermogenesis (DIT) are known to influence long term maintenance of weight loss following bariatric surgery. Although it is known that fat free mass (FFM) contributes to REE to a greater extent than fat mass (FM), there has been relatively little work looking at the REE:FFM ratio and its overall effect on and relationship to weight loss.Aim: To assess weight loss, REE and REE:MMT ratio in pati...